GeneTex

  • Country / Location Selection

United States (US)

p63 antibody [4A4]

Anti-p63 antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX23239
Anti-p63 antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX23239

Cat. No. GTX23239

Reference 6

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4A4

Isotype

 IgG2a

Application

 ICC/IF, IHC-P

Reactivity

 Human, Mouse
Package
500 μl ($399)
See all p63 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:100-1:200

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval is recommended.
Not tested in other applications.

Calculated MW

77 kDa. ( Note )

Positive Control

Skin, prostate

Product Note

Recognizes all known isotypes of p63

PROPERTIES

Form

Liquid

Buffer

Tris-HCI buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment corresponding to Human p63 aa 1-205.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_384982

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor protein p63 , AIS , B(p51A) , B(p51B) , EEC3 , KET , LMS , NBP , OFC8 , RHS , SHFM4 , TP53CP , TP53L , TP73L , p40 , p51 , p53CP , p63 , p73H , p73L

Cellular Localization

Nucleus

Background

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

Database

Research Area

DATA IMAGES

Anti-p63 antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX23239

GTX23239 IHC-P Image

The data was published in the journal Int J Mol Sci in 2017.PMID: 28672879

Anti-p63 antibody [4A4] used in IHC (Paraffin sections) (IHC-P). GTX23239

GTX23239 IHC-P Image

The data was published in the journal Head Face Med in 2012. PMID: 23241143

REFERENCE

Application Reference

Sylvain Lefort et al. Cell Death Differ 2022; 29 (1) : 54-64 De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer.
Application : IHC-P
Reactivity : Human
Shin JW et al. Int J Mol Sci 2017; 18 (7) The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis.
Application : IHC-P
Reactivity : Human
Hobbs RP et al. Oncogene 2016; (Epub) Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.
Application : ICC/IF
Reactivity : Mouse
Sun Y et al. Int J Oral-Med Sci. 2012; 10(4):336-43. : 10(4):336-43. An Immunohistochemical Study of Oral Carcinoma Cuniculatum.
Application : IHC-P
Reactivity : Human
Neunzehn J et al. Head Face Med 2012; 8 : 35 Investigation of biomaterials by human epithelial gingiva cells: an in vitro study.
Application : IHC-P
Reactivity : Human
Show More +
Submit a Reference

REVIEW

There are currently no reviews for p63 antibody [4A4] (GTX23239). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399