Proteasome 20S alpha 1 antibody [N1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||30 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , U87-MG , MCF-7 , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||proteasome (prosome, macropain) subunit, alpha type, 1|
|Product Description||Rabbit Polyclonal antibody to Proteasome 20S alpha 1 (proteasome (prosome, macropain) subunit, alpha type, 1)|
|Background||The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.|
|Synonyms||HC2 antibody, MGC14542 antibody, MGC14575 antibody, MGC14751 antibody, MGC1667 antibody, MGC21459 antibody, MGC22853 antibody, MGC23915 antibody, NU antibody, PROS30 antibody, PSMA1 antibody, proteasome nu chain antibody, protein P30-33K antibody, macropain subunit nu antibody, PROS-30 antibody, macropain subunit C2 antibody, multicatalytic endopeptidase complex subunit C2 antibody, "proteasome subunit, alpha-type, 1 antibody", proteasome component C2 antibody, proteasome subunit nu antibody, proteasome subunit alpha type-1 antibody, 30 kDa prosomal protein antibody, "proteasome (prosome, macropain) subunit, alpha type, 1 antibody"|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Proteasome 20S alpha 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Zebrafish (95%), Xenopus laevis (95%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%)|