Proteasome 20S alpha 6 antibody
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||27 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , mouse liver , rat liver|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||proteasome (prosome, macropain) subunit, alpha type, 6|
|Product Description||Rabbit Polyclonal antibody to Proteasome 20S alpha 6 (proteasome (prosome, macropain) subunit, alpha type, 6)|
|Background||The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq]|
|Synonyms||IOTA antibody, MGC22756 antibody, MGC2333 antibody, MGC23846 antibody, PROS27 antibody, p27K antibody, PSMA6 antibody, 27 kDa prosomal protein antibody, multicatalytic endopeptidase complex iota chain antibody, macropain iota chain antibody, prosomal P27K protein antibody, proteasome subunit alpha type-6 antibody, PROS-27 antibody, macropain subunit iota antibody, proteasome iota chain antibody, proteasome subunit iota antibody, proteasome (prosome, macropain) subunit, alpha type, 6 antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Proteasome 20S alpha 6. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Xenopus laevis (87%), Pig (98%), Chicken (96%), Sheep (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)|