|Full Name||proteasome (prosome, macropain) subunit, beta type, 7|
|Product Description||Rabbit Polyclonal antibody to Proteasome 20S beta 7 (proteasome (prosome, macropain) subunit, beta type, 7)|
|Background||The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq]|
|Synonyms||Z antibody, PSMB7 antibody, proteasome subunit Z antibody, macropain chain Z antibody, proteasome subunit beta 7 antibody, proteasome subunit beta type-7 antibody, proteasome subunit alpha antibody, multicatalytic endopeptidase complex chain Z antibody, proteasome catalytic subunit 2 antibody, "proteasome (prosome, macropain) subunit, beta type, 7 antibody"|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Proteasome 20S beta 7. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (95%), Dog (95%), Pig (93%), Chicken (84%), Rhesus Monkey (98%), Bovine (95%)|