|Full Name||pyruvate dehydrogenase (lipoamide) alpha 1|
|Product Description||Rabbit Polyclonal antibody to Pyruvate Dehydrogenase E1 alpha (pyruvate dehydrogenase (lipoamide) alpha 1)|
|Background||The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 22.214.171.124); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 126.96.36.199). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]|
|Synonyms||PDHA antibody, PDHCE1A antibody, PHE1A antibody, PDHA1 antibody, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial antibody, pyruvate dehydrogenase complex, E1-alpha polypeptide 1 antibody, PDHE1-A type I antibody, pyruvate dehydrogenase (lipoamide) alpha 1 antibody|
|Cellular Localization||Mitochondrion matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Pyruvate Dehydrogenase E1 alpha. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Xenopus laevis (91%), Chicken (90%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%)|