|Full Name||quaking homolog, KH domain RNA binding (mouse)|
|Product Description||Goat polyclonal antibody to Quaking / QKI|
|Background||RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. |
|Synonyms||DKFZp586I0923, Hqk, QK3, Quaking / QKI, homolog of mouse quaking QKI (KH domain RNA binding protein), quaking homolog, KH domain RNA binding, RNA binding protein HQK, QK, QKI, QK1|
|Specificity||This antibody is specific for Quaking / QKI.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Dog, Pig, Bovine|