|Full Name||recombination activating gene 2|
|Product Description||Rabbit Polyclonal antibody to RAG2 (recombination activating gene 2)|
|Background||This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq]|
|Synonyms||RAG-2 antibody, RAG2 antibody, V(D)J recombination-activating protein 2 antibody, recombination activating gene 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RAG2. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Mouse (85%), Pig (90%), Rabbit (91%), Bovine (91%)|