|Full Name||receptor (G protein-coupled) activity modifying protein 1|
|Product Description||Rabbit polyclonal antibody to RAMP1 (receptor (G protein-coupled) activity modifying protein 1)|
|Background||The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq]|
|Synonyms||RAMP1 antibody, receptor activity-modifying protein 1 antibody, receptor activity modifying protein 1 antibody, receptor (calcitonin) activity modifying protein 1 antibody, CRLR activity-modifying protein 1 antibody, calcitonin-receptor-like receptor activity-modifying protein 1 antibody, calcitonin receptor-like receptor activity modifying protein 1 antibody, receptor (G protein-coupled) activity modifying protein 1 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus Tropicalis, Pig, Guinea pig|
|Predict Reactivity Note||Mouse (93%), Rat (93%), Xenopus Tropicalis (87%), Pig (86%), Guinea pig (80%)|