Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||20 kDa (note)
|Positive Controls||Jurkat , Raji , K562 , THP-1 , HL-60 , NCI-H929|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||receptor (G protein-coupled) activity modifying protein 2|
|Product Description||Rabbit Polyclonal antibody to RAMP2 (receptor (G protein-coupled) activity modifying protein 2)|
|Background||The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq]|
|Synonyms||RAMP2 antibody, calcitonin receptor-like receptor activity modifying protein 2 antibody, receptor activity-modifying protein 2 antibody, receptor activity modifying protein 2 antibody, calcitonin-receptor-like receptor activity-modifying protein 2 antibody, receptor-activity-modifying protein 2 antibody, receptor (calcitonin) activity modifying protein 2 antibody, CRLR activity-modifying protein 2 antibody, receptor (G protein-coupled) activity modifying protein 2 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (80%), Pig (86%), Bovine (93%)|