|Full Name||RAN, member RAS oncogene family|
|Product Description||Rabbit Polyclonal antibody to RAN (RAN, member RAS oncogene family)|
|Background||RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq]|
|Synonyms||ARA24 antibody, Gsp1 antibody, TC4 antibody, RAN antibody, androgen receptor-associated protein 24 antibody, OK/SW-cl.81 antibody, GTPase Ran antibody, guanosine triphosphatase Ran antibody, GTP-binding nuclear protein Ran antibody, ras-related nuclear protein antibody, ras-like protein TC4 antibody, RanGTPase antibody, member RAS oncogene family antibody, "RAN, member RAS oncogene family antibody"|
|Cellular Localization||Nucleus , Cytoplasm , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RAN. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Drosophila, Dog, Chicken, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Zebrafish (95%), Drosophila (90%), Dog (100%), Chicken (98%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)|