|Full Name||tumor necrosis factor (ligand) superfamily, member 11|
|Product Description||Rabbit polyclonal antibody to RANKL (CD254) (tumor necrosis factor (ligand) superfamily, member 11)|
|Background||This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]|
|Synonyms||CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNFSF11 antibody, osteoprotegerin ligand antibody, receptor activator of nuclear factor kappa-B ligand antibody, receptor activator of nuclear factor kappa B ligand antibody, tumor necrosis factor ligand superfamily member 11 antibody, osteoclast differentiation factor antibody, TNF-related activation-induced cytokine antibody, "tumor necrosis factor (ligand) superfamily, member 11 antibody"|
|Cellular Localization||Isoform 1: Cell membrane; Single-pass type II membrane protein , Isoform 3: Cell membrane; Single-pass type II membrane protein , Isoform 2: Cytoplasm , Tumor necrosis factor ligand superfamily member 11 , soluble form: Secreted |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RANKL. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (100%)|