| Full Name | chemokine (C-C motif) ligand 5 |
| Product Description | Mouse Monoclonal antibody [12K10] to RANTES |
| Background | This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq, Jul 2008] |
| Synonyms | D17S136E Antibody , TCP228 Antibody , chemokine (C-C motif) ligand 5 Antibody , SISd Antibody , SCYA5 Antibody , CCL5 Antibody , RANTES Antibody |
| Specificity | This antibody was selected for its ability to detect human CCL-5 protein |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 12K10 |
| Target | RANTES |
| Isotype | IgG1 |
| Immunogen | Human recombinant CCL-5 |
| Antigen Species | Human |
| Species Reactivity | Human |