|Full Name||telomeric repeat binding factor 2, interacting protein|
|Product Description||Goat polyclonal antibody to RAP1 / TERF2IP|
|Background||Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. |
|Synonyms||telomeric repeat binding factor 2, interacting protein, dopamine receptor interacting protein 5, TRF2-interacting telomeric RAP1 protein, DRIP5, TERF2IP, RAP1, dopamine receptor interacting protein5, telomeric repeat binding factor2, interacting protein, RAP1 / TERF2IP, TRF2interacting telomeric RAP1 protein|
|Cellular Localization||Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. |
|Specificity||This antibody is specific for RAP1 / TERF2IP.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine, Dog|