Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||21 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||RAP1A, member of RAS oncogene family|
|Product Description||Rabbit polyclonal antibody to RAP1A (RAP1A, member of RAS oncogene family)|
|Background||The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]|
|Synonyms||KREV-1 antibody, KREV1 antibody, RAP1 antibody, SMGP21 antibody, RAP1A antibody, ras-related protein Rap-1A antibody, RAS-related protein RAP1A antibody, C21KG antibody, GTP-binding protein smg p21A antibody, G-22K antibody, Ras-related protein Krev-1 antibody, "RAP1A, member of RAS oncogene family antibody"|
|Cellular Localization||Cell membrane; Lipid-anchor |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RAP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Xenopus laevis (97%), Rhesus Monkey (100%), Bovine (100%)|