|Full Name||Rap guanine nucleotide exchange factor (GEF) 5|
|Product Description||Rabbit polyclonal antibody to RAPGEF5 (Rap guanine nucleotide exchange factor (GEF) 5)|
|Background||Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]|
|Synonyms||GFR antibody, KIAA0277 antibody, MR-GEF antibody, REPAC antibody, RAPGEF5 antibody, related to Epac antibody, guanine nucleotide exchange factor for Rap1 antibody, M-Ras-regulated Rap GEF antibody, M-Ras-regulated GEF antibody, rap guanine nucleotide exchange factor 5 antibody, Rap guanine nucleotide exchange factor (GEF) 5 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human RAPGEF5. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rhesus Monkey|
|Predict Reactivity Note||Mouse (85%), Rhesus Monkey (98%)|