|Full Name||RAS p21 protein activator 4|
|Product Description||Rabbit Polyclonal antibody to RASA4 (RAS p21 protein activator 4)|
|Background||This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CAPRI antibody, FLJ59070 antibody, GAPL antibody, KIAA0538 antibody, MGC131890 antibody, RASA4B antibody, RASA4 antibody, ras GTPase-activating protein 4 antibody, Ca2+-promoted Ras inactivator antibody, rasGAP-activating-like protein 2 antibody, calcium-promoted Ras inactivator antibody, RAS p21 protein activator 4 antibody|
|Cellular Localization||Cytoplasm , cytosol , Cell membrane; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human RASA4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (84%)|