|Full Name||Ras association (RalGDS/AF-6) domain family member 1|
|Product Description||Rabbit polyclonal antibody to RASSF1 (Ras association (RalGDS/AF-6) domain family member 1)|
|Background||This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||123F2 antibody, NORE2A antibody, RASSF1A antibody, RDA32 antibody, REH3P21 antibody, RASSF1 antibody, tumor suppressor protein RDA32 antibody, pancreas-specific ras association domain family 1 protein antibody, ras association domain-containing protein 1 antibody, WUGSC:H_LUCA12.5 antibody, cardiac-specific ras association domain family 1 protein antibody, Ras association (RalGDS/AF-6) domain family member 1 antibody|
|Cellular Localization||Isoform A: Cytoplasm , cytoskeleton , Centrosome , Spindle , Isoform C: Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RASSF1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Sheep, Bovine|
|Predict Reactivity Note||Mouse (91%), Rat (91%), Sheep (96%), Bovine (87%)|