|Full Name||retinol binding protein 3, interstitial|
|Product Description||Rabbit Polyclonal antibody to RBP3 (retinol binding protein 3, interstitial)|
|Background||Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq]|
|Synonyms||D10S64 antibody, D10S65 antibody, D10S66 antibody, IRBP antibody, RBPI antibody, RBP3 antibody, retinol-binding protein 3 antibody, interphotoreceptor retinoid-binding protein antibody, retinol binding protein 3, interstitial antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix , interphotoreceptor matrix |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human RBP3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat|
|Predict Reactivity Note||Human (100%), Mouse (80%), Rat (81%)|