|Full Name||ret proto-oncogene|
|Product Description||Rabbit Polyclonal antibody to RET (ret proto-oncogene)|
|Background||This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq]|
|Synonyms||HSCR1 Antibody, MEN2A Antibody, PTC Antibody, ret proto-oncogene Antibody, RET51 Antibody, CDHF12 Antibody, CDHR16 Antibody, RET-ELE1 Antibody, MTC1 Antibody, MEN2B Antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human RET. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog|
|Predict Reactivity Note||Mouse (94%), Rat (93%), Dog (92%)|