|Full Name||resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)|
|Product Description||Rabbit Polyclonal antibody to RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans))|
|Background||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.|
|Synonyms||MGC104517 antibody, MGC131931 antibody, MGC148073 antibody, MGC148074 antibody, RIC8 antibody, RIC8A antibody, synembryn antibody, synembryn-A antibody, resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RIC8A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Bovine (100%)|