|Applications||ICC/IF, IHC-Fr, IHC-P, WB|
Not tested in other applications.
| IHC (Frozen sections)||Assay-dependent dilution
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||57 kDa (note)
|Positive Controls||THP-1 , A549 , H1299 , HCT116 , mouse B lymphocyte , mouse thymocyte , mouse T lymphocyte|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||receptor-interacting serine-threonine kinase 3|
|Product Description||Rabbit Polyclonal antibody to RIP3 (receptor-interacting serine-threonine kinase 3)|
|Background||The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq]|
|Synonyms||RIP3 antibody, RIPK3 antibody, receptor interacting protein 3 antibody, receptor-interacting serine/threonine-protein kinase 3 antibody, RIP-like protein kinase 3 antibody, receptor-interacting protein 3 antibody, RIP-3 antibody, receptor-interacting serine-threonine kinase 3 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RIP3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|