|Full Name||ring finger protein 144B|
|Product Description||Rabbit polyclonal antibody to RNF144B (ring finger protein 144B)|
|Background||E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.|
|Synonyms||IBRDC2 antibody, KIAA0161 antibody, MGC71786 antibody, PIR2 antibody, bA528A10.3 antibody, p53RFP antibody, RNF144B antibody, E3 ubiquitin-protein ligase RNF144B antibody, IBR domain-containing protein 2 antibody, IBR domain containing 2 antibody, p53-inducible RING finger protein antibody, ring finger protein 144B antibody|
|Cellular Localization||Membrane; Single-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RNF144B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (87%), Rat (86%), Rhesus Monkey (98%), Bovine (93%)|