|Full Name||ring finger protein 2|
|Product Description||Goat polyclonal antibody to RNF2 / dinG|
|Background||The Polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer, while targeted deletions of members of this family generally have lethal phenotypes. Two-hybrid and immunoprecipitation studies have found that the PcG proteins form at least two large nonoverlapping protein complexes. The first type of complex, known as class I, contains homologues of the drosophila proteins esc and E(z) and has been shown to associate with histone deacetylase activity. The second type of complex (class II) includes homologues of Pc, Psc, Ph, Ring, and Scm. No enzymatic activity has been ascribed to this second group of proteins. |
|Synonyms||GS1-120K12.1, DING, GS1120K12.1, ring finger protein 2, BAP1, ring finger protein2, RNF2, BAP-1, RNF2 / dinG, HIPI3, RING1B, RING2, BAP 1|
|Cellular Localization||Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in no|
|Specificity||This antibody is specific for RNF2 / dinG.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Bovine|