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1 .GTX59604 ROCK1 (cleaved) antibody [12M03]

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ROCK1 (cleaved) antibody [12M03]


  • Host / ClonalityMouse Monoclonal
  • Clone Name12M03
  • ApplicationsWB
  • Species reactivityHuman, Mouse
Cat No: GTX59604
Package Price Qty
100 μgUSD 349.00
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  • Datasheet
  • Application Information: ROCK1 (cleaved) antibody [12M03]

Catalog Number GTX59604
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Product Name ROCK1 (cleaved) antibody [12M03]
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ApplicationsWB
Application NoteWestern blotting (1-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate treated with camptothecin (2 µM for 6-8 hours) can be used as a positive control. The antibody has been selected for its ability to recognize the cleaved ROCK-1 in Western blotting. It does not recognize the full length protein.
Form SuppliedLiquid
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration)
PurificationAffinity purified

  • Specifications: ROCK1 (cleaved) antibody [12M03]

Full NameRho-associated, coiled-coil containing protein kinase 1
BackgroundROCK-1 (Rho-associated coiled coil-containing protein kinase 1) has been found to be a new caspase-3 substrate. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain. During apoptosis, ROCK-1 is cleaved by caspase-3 at the conserved DETD1113/G sequence and its C-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3 mediated cleavage and activation of ROCK-1 induces phosphorylation of MLC and membrane blebbing, the early events in the execution phase of apoptosis.
SynonymsP160ROCK, MGC131603, ROCK1, EC2.7.11.1, EC 2.7.11.1, MGC43611, ROCK-1 (cleaved), cleaved ROCK-1
Cellular LocalizationAssociated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.
SpecificityThis antibody is specific for ROCK-1 (cleaved).
HostMouse
ClonalityMonoclonal
Clone Name12M03
IsotypeIgG
Species ReactivityHuman, Mouse
ConjugationUnconjugated

  • Storage Conditions: ROCK1 (cleaved) antibody [12M03]

Storage BufferPBS (pH 7.2) containing 50% glycerol, 1% BSA, 0.02% thimerosal
Storage InstructionThe antibody solution should be gently mixed before use. Stored at -20 °C for future use.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cell Biology > Cell adhesion > Cell-cell adhesion > Leukocyte
  • Cell Biology > Cytoskeleton
  • Signal Transduction > ECM/Cytoskeleton > Cytoskeleton
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ROCK1 (cleaved) antibody [12M03] validated data
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