| Full Name | Rho-associated, coiled-coil containing protein kinase 1 |
| Product Description | Mouse Monoclonal antibody [12M03] to ROCK1 (cleaved) |
| Background | ROCK-1 (Rho-associated coiled coil-containing protein kinase 1) has been found to be a new caspase-3 substrate. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain. During apoptosis, ROCK-1 is cleaved by caspase-3 at the conserved DETD1113/G sequence and its C-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3 mediated cleavage and activation of ROCK-1 induces phosphorylation of MLC and membrane blebbing, the early events in the execution phase of apoptosis. |
| Synonyms | P160ROCK, MGC131603, ROCK1, EC2.7.11.1, EC 2.7.11.1, MGC43611, ROCK-1 (cleaved), cleaved ROCK-1 |
| Cellular Localization | Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes. |
| Specificity | This antibody is specific for ROCK-1 (cleaved). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 12M03 |
| Target | ROCK1 (cleaved) |
| Isotype | IgG |
| Species Reactivity | Human, Mouse |