|Full Name||replication protein A2, 32kDa|
|Product Description||Rabbit Polyclonal antibody to RPA32 (phospho Thr21) (replication protein A2, 32kDa)|
|Background||Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.|
|Target||RPA32 (phospho Thr21)|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Human RPA32 (phospho Thr21). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Zebrafish (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)|