|Full Name||retinal pigment epithelium-specific protein 65kDa|
|Product Description||Rabbit polyclonal antibody to RPE65 (retinal pigment epithelium-specific protein 65kDa)|
|Background||This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq]|
|Synonyms||LCA2 antibody, RP20 antibody, mRPE65 antibody, rd12 antibody, sRPE65 antibody, RPE65 antibody, all-trans-retinyl-palmitate hydrolase antibody, p63 antibody, retinoid isomerohydrolase antibody, retinal pigment epithelium-specific 65 kDa protein antibody, RBP-binding membrane protein antibody, retinitis pigmentosa 20 (autosomal recessive) antibody, retinol isomerase antibody, retinal pigment epithelium-specific protein 65kDa antibody|
|Cellular Localization||Cytoplasm (By similarity) , Cell membrane; Lipid-anchor (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RPE65. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Xenopus laevis, Dog, Chicken, Bovine|
|Predict Reactivity Note||Human (100%), Rat (93%), Xenopus laevis (83%), Dog (97%), Chicken (89%), Bovine (98%)|