RPSA antibody [N1C3]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||33 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||ribosomal protein SA|
|Product Description||Rabbit Polyclonal antibody to RPSA (ribosomal protein SA)|
|Background||Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]|
|Synonyms||37LRP antibody, 67LR antibody, LAMBR antibody, LAMR1 antibody, LBP antibody, LRP antibody, p40 antibody, RPSA antibody, multidrug resistance-associated protein MGr1-Ag antibody, laminin binding protein antibody, 40S ribosomal protein SA antibody, 37 kDa laminin receptor antibody, 37/67 kDa laminin receptor antibody, 67 kDa laminin receptor antibody, "67kD, ribosomal protein SA antibody", laminin-binding protein precursor p40 antibody, "laminin receptor 1 (67kD, ribosomal protein SA) antibody", colon carcinoma laminin-binding protein antibody, ribosomal protein SA antibody|
|Cellular Localization||Cell membrane , Cytoplasm (By similarity) , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RPSA. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Dog, Pig, Chicken, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (99%), Zebrafish (92%), Xenopus laevis (95%), Dog (100%), Pig (100%), Chicken (98%), Sheep (99%), Rhesus Monkey (100%), Bovine (99%)|