|Full Name||ribonucleotide reductase M1|
|Product Description||Rabbit Polyclonal antibody to RRM1 (ribonucleotide reductase M1)|
|Background||This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq]|
|Synonyms||R1 antibody, RIR1 antibody, RR1 antibody, RRM1 antibody, ribonucleotide reductase, large subunit antibody, ribonucleotide reductase, R1 subunit antibody, ribonucleoside-diphosphate reductase large subunit antibody, ribonucleotide reductase M1 polypeptide antibody, ribonucleoside-diphosphate reductase subunit M1 antibody, ribonucleotide reductase M1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RRM1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (97%), Zebrafish (87%), Xenopus laevis (84%), Chicken (92%), Rhesus Monkey (98%), Bovine (96%)|