|Full Name||RuvB-like 1 (E. coli)|
|Product Description||Rabbit Polyclonal antibody to RUVBL1 (RuvB-like 1 (E. coli))|
|Background||Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation. |
|Synonyms||ECP54 antibody, INO80H antibody, NMP238 antibody, PONTIN antibody, Pontin52 antibody, RVB1 antibody, TIH1 antibody, TIP49 antibody, TIP49A antibody, RUVBL1 antibody, INO80 complex subunit H antibody, pontin 52 antibody, 49 kDa TATA box-binding protein-interacting protein antibody, nuclear matrix protein 238 antibody, TATA binding protein interacting protein 49 kDa antibody, TIP60-associated protein 54-alpha antibody, 49 kDa TBP-interacting protein antibody, ruvB-like 1 antibody, TAP54-alpha antibody, ECP-54 antibody, 54 kDa erythrocyte cytosolic protein antibody, RuvB (E coli homolog)-like 1 antibody, NMP 238 antibody, RuvB-like 1 (E. coli) antibody|
|Cellular Localization||Nucleus matrix , Nucleus , nucleoplasm , Cytoplasm , Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human RUVBL1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Zebrafish (97%), Xenopus laevis (97%), Chicken (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%)|