|Full Name||RAD17 homolog (S. pombe)|
|Product Description||Rabbit polyclonal antibody to Rad17 (RAD17 homolog (S. pombe))|
|Background||The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq]|
|Synonyms||CCYC antibody, FLJ41520 antibody, HRAD17 antibody, R24L antibody, RAD17SP antibody, RAD24 antibody, RAD17 antibody, cell cycle checkpoint protein (RAD17) antibody, cell cycle checkpoint protein RAD17 antibody, RAD1 homolog antibody, RF-C activator 1 homolog antibody, RF-C/activator 1 homolog antibody, Rad17-like protein antibody, RAD17 homolog (S. pombe) antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Rad17. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (80%), Rat (80%), Bovine (88%)|