RanGAP1 antibody [N1N3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||64 kDa (note)
|Positive Controls||293T , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||Ran GTPase activating protein 1|
|Product Description||Rabbit polyclonal antibody to RanGAP1 (Ran GTPase activating protein 1)|
|Background||RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]|
|Synonyms||Fug1 antibody, KIAA1835 antibody, MGC20266 antibody, SD antibody, RANGAP1 antibody, segregation distorter homolog antibody, ran GTPase-activating protein 1 antibody, segregation distortion antibody, Ran GTPase activating protein 1 antibody|
|Cellular Localization||Cytoplasm , Nucleus membrane; Peripheral membrane protein; Cytoplasmic side , Kinetochore (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human RanGAP1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Xenopus laevis (86%), Chicken (90%), Bovine (96%)|