|Full Name||renalase, FAD-dependent amine oxidase|
|Product Description||Goat polyclonal antibody to Renalase (aa 134 to 147)|
|Background||Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. |
|Synonyms||chromosome 10 open reading frame 59, chromosome10 open reading frame59, Renalase (aa134 to147), renalase, FLJ11218, C10orf59, Renalase (aa 134 to 147)|
|Specificity||This antibody is specific for Renalase (aa 134 to 147).|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.