|Product Description||Rabbit Polyclonal antibody to Renin (renin)|
|Background||Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq]|
|Synonyms||FLJ10761 antibody, HNFJ2 antibody, REN antibody, renin precursor, renal antibody, angiotensin-forming enzyme antibody, renin antibody, angiotensinogenase antibody|
|Cellular Localization||Secreted , Membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Renin. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Rhesus Monkey (98%), Chimpanzee (100%)|