|Full Name||retinoic acid receptor, alpha|
|Product Description||Rabbit Polyclonal antibody to Retinoic Acid Receptor alpha (retinoic acid receptor, alpha)|
|Background||Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM]|
|Synonyms||NR1B1 antibody, RAR antibody, RARA antibody, RAR-alpha antibody, retinoic acid receptor alpha antibody, retinoic acid nuclear receptor alpha variant 1 antibody, nuclear receptor subfamily 1 group B member 1 antibody, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form antibody, retinoic acid nuclear receptor alpha variant 2 antibody, "retinoic acid receptor, alpha polypeptide antibody", "retinoic acid receptor, alpha antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Retinoic Acid Receptor alpha. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Dog, Chicken, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Xenopus laevis (94%), Dog (98%), Chicken (97%), Bovine (100%)|