| Background | S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes and Schwann's cells. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin, and in Langerhans cells in the skin. |
| Synonyms | S100, 282059, 431787, S100a1, S100B |
| Cellular Localization | Cytoplasmic |
| Specificity | This antibody reacts with cow S-100 protein A and B. It shows strong cross reactivity with human S-100 A and B. In the brain, it labels glial and ependymal cells. Melanocytes and Langerhans cells of the skin are also stained with this antibody. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Affinity purified S-100 protein isolated from cow brain. |
| Antigen Species | Bovine |
| Species Reactivity | Human, Bovine |
| Conjugation | Unconjugated |