|Full Name||S100 calcium binding protein B|
|Product Description||Rabbit Polyclonal antibody to S100B (S100 calcium binding protein B)|
|Background||The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq]|
|Synonyms||S100-B Antibody , S100 calcium binding protein B Antibody , S100beta Antibody , NEF Antibody , S100 Antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Full length human S100 beta Recombinant protein.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rabbit (100%), Chicken (84%), Rhesus Monkey (98%), Bovine (96%)|