|Full Name||splicing factor 3b, subunit 3, 130kDa|
|Product Description||Rabbit Polyclonal antibody to SAP130 (splicing factor 3b, subunit 3, 130kDa)|
|Background||This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq]|
|Synonyms||KIAA0017 antibody, RSE1 antibody, SAP130 antibody, SF3b130 antibody, STAF130 antibody, SF3B3 antibody, "pre-mRNA splicing factor SF3b, 130 kDa subunit antibody", splicing factor 3B subunit 3 antibody, pre-mRNA-splicing factor SF3b 130 kDa subunit antibody, spliceosome-associated protein 130 antibody, SAP 130 antibody, "splicing factor 3b, subunit 3, 130kDa antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human SAP130. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Rat (100%), Zebrafish (95%), Bovine (100%)|