|Full Name||squamous cell carcinoma antigen recognized by T cells|
|Product Description||Rabbit polyclonal antibody to SART1 (squamous cell carcinoma antigen recognized by T cells)|
|Background||This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq]|
|Synonyms||Ara1 antibody, HOMS1 antibody, MGC2038 antibody, SART1259 antibody, SNRNP110 antibody, Snu66 antibody, SART1 antibody, U4/U6.U5 tri-snRNP-associated protein 1 antibody, squamous cell carcinoma antigen recognised by T cells antibody, hSnu66 antibody, SART1(259) protein antibody, IgE autoantigen antibody, SNU66 homolog antibody, SART-1 antibody, small nuclear ribonucleoprotein 110kDa (U4/U6.U5) antibody, U4/U6.U5 tri-snRNP-associated 110 kDa protein antibody, hSART-1 antibody, squamous cell carcinoma antigen recognized by T cells 1 antibody, SART1(800) protein antibody, squamous cell carcinoma antigen recognized by T cells antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human SART1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (81%), Bovine (99%)|