|Full Name||sodium channel, nonvoltage-gated 1 alpha|
|Product Description||Rabbit Polyclonal antibody to SCNN1A (amiloride-sensitive sodium channel subunit alpha)|
|Background||Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||BESC2 antibody, ENaCa antibody, ENaCalpha antibody, FLJ21883 antibody, SCNEA antibody, SCNN1 antibody, SCNN1A antibody, alpha ENaC-2 antibody, amiloride-sensitive epithelial sodium channel alpha subunit antibody, amiloride-sensitive sodium channel subunit alpha 2 antibody, epithelial Na(+) channel subunit alpha antibody, amiloride-sensitive sodium channel subunit alpha antibody, nasal epithelial sodium channel alpha subunit antibody, alpha-NaCH antibody, nonvoltage-gated sodium channel 1 subunit alpha antibody, alpha-ENaC antibody, "sodium channel, nonvoltage-gated 1 alpha antibody"|
|Cellular Localization||Apical cell membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SCNN1A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rabbit, Bovine, Guinea pig|
|Predict Reactivity Note||Mouse (84%), Rat (85%), Pig (85%), Rabbit (89%), Bovine (85%), Guinea pig (83%)|