|Full Name||succinate dehydrogenase complex, subunit B, iron sulfur (Ip)|
|Product Description||Rabbit Polyclonal antibody to SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))|
|Background||Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]|
|Synonyms||FLJ92337 antibody, IP antibody, PGL4 antibody, SDH antibody, SDH1 antibody, SDH2 antibody, SDHIP antibody, SDHB antibody, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial antibody, iron-sulfur subunit of complex II antibody, succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody|
|Cellular Localization||Mitochondrion inner membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SDHB. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Xenopus laevis, Dog, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Zebrafish (90%), Xenopus laevis (93%), Dog (98%), Pig (98%), Chicken (90%), Rhesus Monkey (100%), Bovine (96%)|