|Full Name||sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F|
|Product Description||Rabbit polyclonal antibody to SEMA3F (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F)|
|Background||The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM]|
|Synonyms||SEMA-IV antibody, SEMA4 antibody, SEMAK antibody, SEMA3F antibody, semaphorin-3F antibody, sema IV antibody, "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3F antibody", semaphorin III/F antibody, sema III/F antibody, semaphorin IV antibody, "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F antibody"|
|Cellular Localization||Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human SEMA3F. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (95%), Rat (93%)|