|Full Name||septin 2|
|Product Description||Goat polyclonal antibody to SEPT2|
|Background||Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. |
|Synonyms||hNedd5, SEPT2, Pnutl3, KIAA0158, septin2, NEDD5, neural precursor cell expressed, developmentally down-regulated 5, septin 2, SEPT2, neural precursor cell expressed, developmentally downregulated5, DIFF6, neural precursor cell expressed, developmentally downregulated 5|
|Cellular Localization||In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the|
|Specificity||This antibody is specific for SEPT2.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|