|Full Name||ATPase, Ca++ transporting, cardiac muscle, slow twitch 2|
|Product Description||Rabbit Polyclonal antibody to SERCA2 ATPase (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)|
|Background||This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||ATP2B antibody, DAR antibody, DD antibody, DKFZp686P0211 antibody, FLJ20293 antibody, FLJ38063 antibody, MGC45367 antibody, SERCA2 antibody, ATP2A2 antibody, "ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2 antibody", "calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform antibody", cardiac Ca2+ ATPase antibody, calcium pump 2 antibody, SR Ca(2+)-ATPase 2 antibody, sarcoplasmic/endoplasmic reticulum calcium ATPase 2 antibody, endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody, "ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 antibody"|
|Cellular Localization||Endoplasmic reticulum membrane , Sarcoplasmic reticulum membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SERCA2 ATPase. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Dog, Cat, Pig, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Xenopus laevis (94%), Dog (99%), Cat (98%), Pig (99%), Rabbit (98%), Chicken (95%), Bovine (98%)|