|Full Name||sestrin 1|
|Product Description||Rabbit Polyclonal antibody to SESN1 (sestrin 1)|
|Background||This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq]|
|Synonyms||MGC138241 antibody, MGC142129 antibody, PA26 antibody, SEST1 antibody, SESN1 antibody, p53 activated gene 26 antibody, p53 regulated PA26 nuclear protein antibody, sestrin-1 antibody, sestrin 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SESN1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (96%), Xenopus laevis (81%), Bovine (96%)|