|Full Name||SET domain containing (lysine methyltransferase) 7|
|Product Description||Rabbit Polyclonal antibody to SETD7 (SET domain containing (lysine methyltransferase) 7)|
|Background||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.|
|Synonyms||FLJ21193 antibody, KIAA1717 antibody, KMT7 antibody, SET7 antibody, SET7/9 antibody, SET9 antibody, SETD7 antibody, histone H3-K4 methyltransferase SETD7 antibody, SET domain-containing protein 7 antibody, histone H3-lysine 4-specific methyltransferase antibody, H3-K4-HMTase SETD7 antibody, histone-lysine N-methyltransferase SETD7 antibody, lysine N-methyltransferase 7 antibody, SET domain containing (lysine methyltransferase) 7 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SETD7. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey|
|Predict Reactivity Note||Mouse (96%), Rat (97%), Rhesus Monkey (100%)|