|Applications||IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||68 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Raji , NIH-3T3 , rat liver , *U2OS|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||protein tyrosine phosphatase, non-receptor type 6|
|Product Description||Rabbit Polyclonal antibody to SHP1 (protein tyrosine phosphatase, non-receptor type 6)|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]|
|Synonyms||HCP antibody, HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody, PTPN6 antibody, hematopoietic cell protein-tyrosine phosphatase antibody, hematopoietic cell phosphatase antibody, protein-tyrosine phosphatase SHP-1 antibody, protein-tyrosine phosphatase 1C antibody, tyrosine-protein phosphatase non-receptor type 6 antibody, "protein tyrosine phosphatase, non-receptor type 6 antibody"|
|Cellular Localization||Cytoplasm , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SHP1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chicken (80%), Bovine (94%)|