|Full Name||protein tyrosine phosphatase, non-receptor type 11|
|Product Description||Rabbit Polyclonal antibody to SHP2 (protein tyrosine phosphatase, non-receptor type 11)|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]|
|Synonyms||BPTP3 antibody, CFC antibody, MGC14433 antibody, NS1 antibody, PTP-1D antibody, PTP2C antibody, SH-PTP2 antibody, SH-PTP3 antibody, SHP2 antibody, PTPN11 antibody, PTP-2C antibody, protein-tyrosine phosphatase 1D antibody, tyrosine-protein phosphatase non-receptor type 11 antibody, protein tyrosine phosphatase-2 antibody, protein-tyrosine phosphatase 2C antibody, protein tyrosine phosphatase, non-receptor type 11 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human SHP2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Xenopus laevis (95%), Chicken (98%), Rhesus Monkey (100%), Bovine (98%)|