|Full Name||seven in absentia homolog 1 (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to SIAH1 (E3 ubiquitin-protein ligase SIAH1)|
|Background||This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]|
|Synonyms||FLJ08065 antibody, SIAH1A antibody, SIAH1 antibody, siah-1a antibody, E3 ubiquitin-protein ligase SIAH1 antibody, seven in absentia homolog 1 (Drosophila) antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SIAH1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (99%), Zebrafish (97%), Xenopus laevis (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)|