|Full Name||seven in absentia homolog 1 (Drosophila)|
|Product Description||Goat polyclonal antibody to SIAH1|
|Background||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. |
|Synonyms||sonic hedgehog homolog, FLJ08065, HUMSIAH, Siah-1, seven in absentia homolog 1, hSIAH1, Siah1, seven in absentia homolog 1 (Drosophila), Siah1a, seven in absentia homolog1 (Drosophila), Siah-1a, seven in absentia homolog1, Siah 1, Siah 1a|
|Cellular Localization||Predominantly cytoplasmic. Partially nuclear. |
|Specificity||This antibody is specific for SIAH1.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Bovine|