|Full Name||single immunoglobulin and toll-interleukin 1 receptor (TIR) domain|
|Product Description||Rabbit Polyclonal antibody to SIGIRR (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain)|
|Background||Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
|Synonyms||MGC110992 antibody, TIR8 antibody, SIGIRR antibody, toll/interleukin-1 receptor 8 antibody, single Ig IL-1-related receptor antibody, single Ig IL-1R-related molecule antibody, single immunoglobulin domain IL1R1 related antibody, single immunoglobulin domain-containing IL1R-related protein antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody|
|Cellular Localization||Membrane; Single-pass type III membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human SIGIRR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (86%), Rat (87%), Pig (90%), Bovine (88%)|